While most Strangers can have their quests met and concluded with Arthur Morgan in Red Dead Redemption 2, a few should be ...

High honor playthrough in RDR2 leads to discounts ... Delving further down into dishonor yields no further rewards, although one mission changes depending on Arthur's honor level.

However, the mission where Arthur contracts the deadly ... In the vanilla version of RDR2, there's no way to save Arthur; he's doomed by the narrative, and his eventual death of TB or a gunshot ...