Cre-loxP technology, a cornerstone in fate mapping and in vivo gene function studies, faces challenges in achieving precise and efficient conditional mutagenesis through inducible systems ...

1. Porreca I. et al. An aptamer-mediated base editing platform for simultaneous knockin and multiple gene knockout for allogeneic CAR-T cells generation. Mol Ther. 2024 Aug 7;32(8):2692-2710.

Over the past 3 decades, the cardiovascular field has benefitted from the development of homologous recombination–mediated gene targeting in mice, including knockout and knockin technologies and ...

The Ca2+ stored in the cellular endoplasmic reticulum (ER) plays a crucial role in protein folding and lipid transfer, and its impairment leads to cellular ER stress. When chronic cellular ER stress ...

They then use CRISPR-Cas9 technology to add the auxin inducible degron (AID) tag to specific endogenous gene loci. Cells express the tagged protein normally until treated with auxin, which induces ...

FDA grants accelerated approval to PTC Therapeutics' Kebilidi, the first brain-administered gene therapy in the U.S. for AADC deficiency. Clinical trials show Kebilidi improved motor function in 8 ...

However, there could be some common threads that run through all cases. A gene called astrotacton 2 (ASTN2) is one ASD-associated gene that was identified several years ago. Mutations in this gene can ...

(RTTNews) - Pfizer Inc. (PFE), Thursday announced that the European Commission has approved conditional marketing authorization for one-time gene therapy Durveqtix. The gene therapy is designed ...

CRISPR is a versatile tool for editing genomes and has recently been approved as a gene therapy treatment for certain blood disorders. When you purchase through links on our site, we may earn an ...