PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...

The quiver of one that can do it all. It’s a concept that many ski, boot and binding manufacturers have been addressing for years. The idea being you have a ski that can handle a variety of conditions ...

Cytoplasmic mtDNA is also recognized by cGAS and leads to increased ... some studies have provided evidence of mtDNA binding to NLRC4 complexes. For example, in 2015, Jabir et al. discovered that ...

Although the cGAS-STING pathway represents a druggable site for decreasing the inflammatory state during IBD, one of the main limitations in the development of cGAS-STING inhibitor-based therapies is ...

State Key Laboratory of Membrane Biology, School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology (Ministry ...

This month's cover highlights the article Organotypic culture of human brain explants as a preclinical model for AI-driven antiviral studies by Emma Partiot, Barbara Gorda, Raphael Gaudin and ...

In this study, we demonstrated that restricting endogenous and exogenous sources of serine in colorectal cancer cells results in mitochondrial dysfunction, leading to mitochondrial DNA (mtDNA) ...

In response to pathogenic microbial infections and other conditions, cyclic GMP-AMP synthase (cGAS ... domain associated protein 3; STAT, signal transducer and activator of transcription; STING, ...

We find that the presence of the PARP1 protein with uncompromised DNA-binding activities is required for PARPi-induced innate immune response. The activation of cGAS-STING signaling induced by various ...