RB Isaac Guerendo was dealing with a hamstring injury. Here are the latest updates leading up to Week 17’s game vs. the Lions ...

Way back in Week 4, 49ers rookie guard Dominick Puni had the wind knocked out of him and had to miss a snap. He hasn’t been ...

Nolan Bianchi, John Niyo, Richard Silva and Bob Wojnowski of The Detroit News offer predictions for Monday's Lions-49ers game ...

After a miserable run with my NFL picks, it's been two straight weeks of solid picking for me. I went 9-6-1 against the ...

The bad injury situation exacerbated for the 49ers during the week with multiple downgrades – Colton McKivitz, Charvarius ...

To make matters worse, offensive lineman Spencer Burford, who was supposed to start at left tackle with Williams and his ...

With nothing left to play for this season, the 49ers will have to hope that Brock Purdy grows from a challenging 2024 ...

San Francisco 49ers running back Isaac Guerendo is expected to play Monday night against the Detroit Lions, according to ESPN ...

The Lions will face a 49ers offensive line that could be starting two tackles signed off practice squads this week ...

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San Francisco 49ers running back Isaac Guerendo is set to return from foot and hamstring injuries and play Monday vs. the ...

Last time the 49ers faced Detroit, they won but also gave up 31 points. And that was in the NFC Championship Game last season ...