Orlando City SC (12-10-7, fourth in the Eastern Conference) vs. Columbus Crew (15-5-8, third in the Eastern Conference) ...

New England Revolution (8-16-4, 14th in the Eastern Conference) vs. Charlotte FC (10-11-8, seventh in the Eastern Conference) ...

Inter Miami CF (19-4-6, first in the Eastern Conference) vs. New York City FC (11-11-7, sixth in the Eastern Conference) ...

FC Cincinnati (17-8-4, second in the Eastern Conference) vs. Nashville SC (8-13-8, 12th in the Western Conference) ...

Minnesota United FC (11-12-6, ninth in the Western Conference) vs. Sporting Kansas City (8-15-7, 13th in the Western Conference) ...