Week 3 matchup vs. Rams with key injuries to McCaffrey, Samuel, and Kittle, testing their depth in this crucial NFC West clash.

When Christian McCaffrey went down, the 49ers could take solace in the fact that they had another versatile and dynamic weapon in Deebo Samuel. For the next two games, the 49ers will be without both as Samuel reported to work with a calf strain that coach Kyle Shanahan would likely keep him out two weeks.