Gene fusions are vital biomarkers for tumor diagnosis and drug development, with precise detection becoming increasingly ...

Targeted testing for gene fusions of interest at the DNA or RNA level is currently in clinical use as it has diagnostic, prognostic, and therapeutic significance. Lead investigator Jonathan ...

Targeted therapy revolutionized cancer treatment, with gene fusions leading the way when the FDA approved imatinib in 2001 to ...

In operable non-small cell lung cancer (NSCLC), molecular residual disease (MRD) detection via circulating tumor DNA (ctDNA) ...

Oct. 9, 2024 — Researchers have created a CRISPR-based rapid molecular diagnostic for two forms of leukemia that are driven by mutations that involve gene fusions. The technology accurately ...

Anchor] Have you heard of NTRK fusion cancer caused by genetic mutations?Although it is unfamiliar, it is a disease that ...

Oct. 28, 2024 — Using state-of-the-art technology, researchers have identified several specific steps needed for CRISPR to become active and perform its gene editing function. These preclinical ...

The FDA is set to decide on four promising therapies in the next two weeks, including a CAR T for acute lymphoblastic ...

For one of these FGFRs, FGFR3, these alterations can take the form of small changes, called mutations, or larger changes where FGFR3 is fused to another gene, called fusions, both of which can ...

Gene therapy and gene editing are on the cutting edge of modern biotechnology. Gene therapies are used to correct genetic abnormalities by introducing genetic material at a cellular level and can ...

Growing up as one of the few Asian kids in a town steeped in Revolutionary War history, I was always straddling two worlds, writes Gene Yu. West Point became my obsession, my ticket to shattering the ...