In these blocks, we identified six genes of known function, including the GR gene sd1, and 123 loci with genes of unknown function. We randomly selected 57 genes from the 123 loci for knockout or ...

Although the inducible isoform of NO synthase (iNOS) mediates late preconditioning (PC), it is unknown whether iNOS gene transfer can replicate the cardioprotective effects of late PC, and the role of ...

∥ Department of Biochemistry, University of Wisconsin—Madison, 433 Babcock Drive, Madison, Wisconsin 53706, United States § Department of Chemistry, University of Wisconsin—Madison, 1101 University ...

ADAR1, adenosine deaminase acting on RNA 1; TRIM25, tripartite motif containing 25; ZCCHC3, zinc finger CCHC-type containing 3; RIG-I, retinoic acid-inducible gene I; Ub, ubiquitin; CARD, caspase ...

Demonstrating efficacy and safety takes time. Many gene-editing companies set very high expectations from the get-go, and, unfortunately, position themselves for potential failure if funds are ...

Cellular responses to oxygen levels are monitored, in part, by the transcriptional activity of the hypoxia inducible factors (HIFs). Under hypoxia, HIFs regulate a variety of pro-angiogenic and ...

aInflammation and Immune-Mediated Diseases Laboratory of Anhui Province, The Key Laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Anhui Institute of Innovative Drugs, School ...