Cytoplasmic mtDNA is also recognized by cGAS and leads to increased ... some studies have provided evidence of mtDNA binding to NLRC4 complexes. For example, in 2015, Jabir et al. discovered that ...

During chronic inflammation, DNA from nearly any source (tumor cells, dead cells, viruses, microorganisms) are sensed by cGAS ... These include GST-like domains, zinc finger domains, leucine zippers, ...

PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...

Concurrent analysis of whole-genome DNA methylation and single-cell RNA sequencing data from COVID-19 patients and controls ...

Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...

The quiver of one that can do it all. It’s a concept that many ski, boot and binding manufacturers have been addressing for years. The idea being you have a ski that can handle a variety of conditions ...

Herpesvirus-encoded microRNAs (v-miRNAs) play a crucial role in modulating host cellular processes to promote viral persistence, immune evasion, and pathogenesis. These v-miRNAs function by targeting ...

Although the cGAS-STING pathway represents a druggable site for decreasing the inflammatory state during IBD, one of the main limitations in the development of cGAS-STING inhibitor-based therapies is ...

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Briefly, endogenous peroxidase activity was blocked with Reagent 1, followed by inhibition of nonspecific binding with Reagent 2 ... CCDC80, coiled‐coil domain‐containing 80; CCL7, chemokine (C‐C ...