The Apoe −/− mouse model is well established for the study of human atherosclerosis. These mice are prone to atherosclerosis. The research team went on to show that TRPM2 deficiency reduces ...

An antibody called bFKB1 improves liver disease and atherosclerosis in a mouse model of metabolic dysfunction-associated steatohepatitis (MASH), which is associated with obesity. The antibody also ...

“There was no traditional model of making a drug ... In one experiment, mice genetically engineered to be highly susceptible to atherosclerosis were fed high-fat diets and assigned to receive ...

Scientists from the Cardiovascular Research Center at the University of Virginia School of Medicine and Astrazeneca plc have developed a new mouse model of cardiovascular disease associated with ...

The drug was given to mice lacking certain transport molecules for the blood lipid cholesterol and that thus serve as an animal model for atherosclerosis (the mice had modifications in the gene ...

ApoE-knockout mice-which develop spontaneous hypercholesterolemia and atherosclerosis after about four months ... the authors write. In this model, yet unknown disease stimuli could modulate in a ...

Bitterroot Bio Inc. presented data on an anti-CD47 hybrid protein, BRB-002, tested in a murine model of atherosclerosis. BRB-002 was tested at 2.5 or 10 mg/kg i.p. 3x/week after a high-fat diet.

Mice receiving bone marrow from Tet2 knockout ... heart disease or early-onset myocardial infarction. In a murine model of atherosclerosis, the loss of Tet2 function in hematopoietic cells ...

The team examined CMA’s role in the condition by first feeding mice a high-fat diet for 12 weeks, and monitored CMA activity in two cell types that malfunction in atherosclerosis. CMA activity ...

“Moreover, no scalable 3D atherosclerosis model is available for the evaluation of potential therapeutics via high-throughput assays.” Cardiovascular disease — primarily caused by atherosclerosis — is ...