Due to the sudden rupture of the aortic wall, aortic dissection is a life-threatening condition that requires immediate ...

A cocktail of FDA-approved cancer drugs, trametinib and rapamycin, boosts the lifespan of lab mice by 30% and might help ...

Atherosclerosis is the buildup of fat and calcium in the walls of blood vessels and represents the most common cause of ...

This study aims to analyze the genetic predictive association between atherosclerosis and intracranial aneurysms, as well as to explore intermediate biomarkers that may mediate the causal relationship ...

The mouse became the predominant model to study atherosclerosis in the 1990s when strains recapitulating familial hypercholesterolemia were created. Mice became widely popular because of rapid ...

Mice and rabbits remain the most common choice for atherosclerosis model creation, followed by pigs and non-human primates. This review aims to summarize the information on the most commonly used ...

"This work comprehensively maps the dynamic biotransformation pathways of biodegradable microplastics within mice. It is of great significance for assessing the biosafety of degradable plastics ...

A mouse biomarker model provides key insights into cellular mediators of immunotherapy response that are present in the tumor microenvironment prior to treatment. The results shown here serve as a ...

We have previously shown that PCSK6 is a key protease modulating smooth muscle cell response in atherosclerosis ... responses and aimed to elucidate its role in a hyperlipidemic mice model.