In addition, genome instability has been long suspected to be the original cause of cell transformation, but whether this applies to most cancer types remains to be determined. Spindle alignment ...

In the absence of FAM110A, proper formation of spindle actin was ... related proteins found in human cells prevent genome instability and the development of cancer. More information: Cecilia ...

In addition, he studies the spindle assembly checkpoint which ensures proper chromosome segregation and is often deregulated in cancer. Joan Massagué, PhD Joan Massagué studies the control of stem ...

These spindle microtubules are responsible for ... Yet, to form correct attachments, they must remain closely connected. In cancer cells, however, we often observe that subdomains uncouple ...