In addition, genome instability has been long suspected to be the original cause of cell transformation, but whether this applies to most cancer types remains to be determined. Spindle alignment ...

depending on the cell type—the mitotic spindle is best disrupted at 150 kHz in pancreatic cancer and NSCLC, and at 200 kHz in ovarian cancer and GBM. Mitosis in noncancerous cells is typically ...

In addition, he studies the spindle assembly checkpoint which ensures proper chromosome segregation and is often deregulated in cancer. Joan Massagué, PhD Joan Massagué studies the control of stem ...