homologous recombination-deficient; LDT, laboratory-developed test; NPV, negative predictive value; PPV, positive predictive value. Fig 4. Functional RAD51 assay performed on FFPE tissue slides.

However, functional assays of HRD are difficult to perform clinically ... This enables precise and massively parallel assessment of molecular phenotypes of homologous recombination deficiency. There ...

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

A successful CRISPR knockin isn’t just about inserting DNA. It’s about ensuring that edit stays functional and reliable over ...

Next-generation-sequencing-based homologous recombination deficiency (HRD) assay based on QIAGEN’s QIAseq xHYB technology, QIAGEN Digital Insight solutions, and Myriad’s proprietary ...

The technique exploits a high level of homologous recombination in the yeast Sacharomyces ... developed previously for complex genomes, for functional, evolutionary, and structural studies ...

Mol Cell Biol. 1998;18:93-101. Johnson RD, Liu N, Jasin M. 1999 Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination. Nature. 1999;401:397-399.