Purpose. The effects of genetic polymorphisms on the pharmacokinetics of calcineurin inhibitors were examined. Pharmacogenetics examines the relationship between single-gene polymorphisms and the ...

Balancing selection, in contrast to directional selection, maintains genetic polymorphism in populations. For example, if heterozygotes at a locus have higher fitness than homozygotes (a scenario ...

Precisely how lowered levels of the gene product, an enzyme called hexoseaminidase A, protect against TB isn't known. Balanced polymorphism may explain why cystic fibrosis is so common- the ...

In Figure 1, scientists used rep-PCR (a form of genomic fingerprinting that involves primers specific to naturally occurring repetitive sequences) to look for genetic polymorphisms in the clinical ...

Study reveals nine gene variants linked to ovarian aging and cancer risk, with implications for reproductive longevity and de ...

DNA-based diets leverage genetic insights to customize nutrition, optimize health, and offer personalized dietary ...

Genetic variability and sex-specific differences may play a role in sickle cell disease (SCD)-related pain; however, more ...

Genomic sequencing of nearly all living kākāpō reveals its variations in plumage color evolved to avoid the sharp eyes of ...

Some research has identified gene polymorphisms involving antipsychotic metabolism and dopamine functioning. TD genetic testing isn't part of standard clinical practice, Zahed pointed out.

Salivary DNA was collected using a DNA Genotek kit (ON, Canada), and TaqMan assays analyzed COL5A1 rs12722 C/T and rs10628678 AGGG/- (deletion) polymorphisms. Risk Assessment and Main Outcomes We ...

Retinoblastoma is a rare, aggressive genetic childhood cancer that results from a mutation that inactivates the RB1 gene, the ...

2006;63(23):2340-2348. MDR1 (ABCB1) T-129C, C1236T, G2677(T,A), C3435T No difference observed for cyclosporine and any CYP3A5 polymorphism Wild-type carriers of MDR1 (ABCB1) 1236 had lower dose ...