The potential target, the FLT1 gene, contributes to the production of a protein, fetal hemoglobin, whose presence is already known to improve the lifespan of people with sickle cell disease.

This leads to leads to anemia, as well as congestion ... fraction of RBCs still contain a mixture of fetal and adult hemoglobin. Because the sickle-cell mutation is present only on the β-globin ...

Patients experience symptoms similar to other forms of anemia ... that leads to the production of fetal hemoglobin, which is not affected by the sickle cell disease mutation.

The potential target, the FLT1 gene, contributes to the production of a protein, fetal hemoglobin, whose presence is already known to improve the lifespan of people with sickle cell disease.

Aruvant is developing ARU-1801, a one-time, potentially curative gene therapy for sickle ... functional fetal hemoglobin in β-thalassemia patients and restore normal red blood cell function.

The quality of life of patients with sickle cell anemia is severely compromised similar to or even worse than patients with other chronic diseases such as arthritis. Patients who responded to ...

A team of researchers has uncovered a previously unrecognized role of mitochondrial protein synthesis in the maintenance of intracellular iron distribution. Disruption of this process was found to ...

Doctors noticed that patients who had sickle cell anemia, a serious hereditary blood ... the gene that tells the body how to make a form of hemoglobin (Hb), the oxygen-carrying molecule in our ...

Feb. 25, 2025 — A bone marrow transplant process is safe and curative for adults with sickle cell disease, according to results of a trial completed at about 20 cancer ... Brains of People With ...

The potential to edit the gene, FLT1, could increase the amount of fetal hemoglobin, a protein that studies have shown helps people with sickle cell disease live longer. The study analyzed the ...