The Mab21 domain of cGAS comprises two lobes ... backbone near the major groove suggests that it may assist in binding to B-form DNA. In support of this, we do not see a substantial perturbation ...

These papers showed that cGAS is an enzyme that is activated upon binding to DNA. Once activated, cGAS combines GTP and ATP to form a cyclic dinucleotide called cyclic GMP–AMP (cGAMP ...

However, previous studies have suggested that the binding affinity of cGAS to DNA is relatively low, how the low binding affinity between cGAS and DNA still efficiently mediates the innate immune ...