The cGAS – STING pathway acts to detect cytosolic DNA and induce an immune response. Upon binding DNA, the protein cyclic GMP-AMP Synthase (cGAS) triggers reaction of GTP and ATP to form cyclic ...

Indeed, for NF-κB and NFAT, the DNA-binding domain is comprised of two Ig-fold regions; the N-terminal Ig-motif is responsible for sequence-specific DNA binding and the linker region that ...