A drug candidate, previously successful at treating severe fatty liver disease, reduces atherosclerosis - a primary driver of cardiovascular death worldwide - in large mammals, a study suggests.

Angiogenesis is a complex, combinatorial process that is regulated by a balance between pro- and anti-angiogenic molecules 1. This balance is disturbed in the setting of pathological angiogenesis ...

By targeting the YAP/TAZ pathway, we were able to significantly reduce the progression of atherosclerosis in our HGPS mouse model. While more research is needed, this opens up the possibility of ...

However, antibiotic treatment reduced the acceleration of atherosclerosis in iWD-fed mice but did not entirely prevent it, suggesting a limited role for microbiota in this model. Adaptive immunity ...