Key takeaways Cholesterol regulation and neuronal vulnerability: The study found that neurons in the locus coeruleus (LC)—a ...

Amyloid fibrils are fibrous protein structures in the brain that are associated with Alzheimer's disease and dementia, among other neurodegenerative disorders. They are often the canonical target ...

Amyloid precursor protein, which generates amyloid-β when broken down, has long been associated with Alzheimer’s disease. But its normal function in the brain has remained relatively mysterious. Over ...

This mechanism, which involves extracellular accumulation of a 56 kDa soluble amyloid-β (Aβ ... rather than permanent neuropathological, brain alterations. Lesné et al. propose that the ...

When doctors suspect Alzheimer's, they can order a blood test to learn whether a patient's brain contains the sticky amyloid plaques that are a hallmark of the disease. But the results of that test ...

Quest Diagnostics has introduced a new blood test aimed at assisting physicians in confirming amyloid brain pathology related ...

Inert amyloid fibrils of the Alzheimer's Aβ-peptide 1–42 (Aβ 42) were incubated overnight with liposomes and various lipids including cholesterol, sphingolipids, gangliosides and brain extract.

A study published in Brain ... such as MRI, CT, and laboratory tests to rule out reversible causes. However, these methods do not identify typical pathologic changes such as beta-amyloid plaques ...

Amyloid-related imaging abnormalities were detected by MRI in 39 participants and included small brain bleeds (microhemorrhages), and swelling of brain tissue (cerebral edema). Two participants ...

Quest Diagnostics has introduced a new blood test aimed at assisting physicians in confirming amyloid brain pathology related to Alzheimer's disease in individuals with mild cognitive impairment ...